Synaptic Vesicle Glycoprotein

Synaptic vesicle glycoproteins, also known as synaptic vesicle proteins, 2SV2 proteins, are the integral membrane glycoprotein found in the central and peripheral nervous systems. SV2 proteins contain 12 membrane-spanning regions and have homology with a group of transporters. It is deduced that the 6 most N-terminal transmembrane regions share high homology with a subfamily of transporters such as the human glucose transporter, while the 6 most C-terminal regions are identified with the plasma membrane transporters for neurotransmitters. Studies have been identified that SV2 proteins mediate the fast Ca2+-dependent synaptic vesicle exocytosis participating in the regulation of neurotransmitters transmission. However, the deficiency of SV2 proteins may lead to presynaptic Ca2+ accumulation during consecutive action potentials, increasing neurotransmitter release thereby inducing epilepsy progression.

There are three isoforms of SV2 proteins: SV2A, SV2B, and SV2C encoded by SV2A, SV2B, and SV2C genes, respectively. SV2A is widely expressed in almost all nerve cells. SV2B is present in SV2A-containing neurons, but not as widely as SV2A. While SV2C is only found in a few brain areas. Here show the three isoforms of SV2 proteins.

Human SV2 Proteins Members

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Magic™ membrane protein production platform – Creative Biolabs

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