Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSynaptic vesicle glycoproteins, also known as synaptic vesicle proteins, 2SV2 proteins, are the integral membrane glycoprotein found in the central and peripheral nervous systems. SV2 proteins contain 12 membrane-spanning regions and have homology with a group of transporters. It is deduced that the 6 most N-terminal transmembrane regions share high homology with a subfamily of transporters such as the human glucose transporter, while the 6 most C-terminal regions are identified with the plasma membrane transporters for neurotransmitters. Studies have been identified that SV2 proteins mediate the fast Ca2+-dependent synaptic vesicle exocytosis participating in the regulation of neurotransmitters transmission. However, the deficiency of SV2 proteins may lead to presynaptic Ca2+ accumulation during consecutive action potentials, increasing neurotransmitter release thereby inducing epilepsy progression.
There are three isoforms of SV2 proteins: SV2A, SV2B, and SV2C encoded by SV2A, SV2B, and SV2C genes, respectively. SV2A is widely expressed in almost all nerve cells. SV2B is present in SV2A-containing neurons, but not as widely as SV2A. While SV2C is only found in a few brain areas. Here show the three isoforms of SV2 proteins.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
