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TAC Design & Construction

Creative Biolabs is a forward-looking CRO company as well as a leading custom service provider in the field of TAC technology. By designing a novel alternative receptor, we can stimulate the nature TCR activation pathway and induce a more stable and controllable immune response. Our novel T cell antigen connector (TAC) engineered T cells can attack cancer cells effectively with strong identification capabilities, as well as low toxicity in the clinic. A wide menu of TAC engineered T cell therapy programs can be tailored to suit particular needs at every stage of your projects.

TAC, T cell antigen connector, is an alternative receptor designed to redirect T cells in a TCR-dependent, MHC-independent manner. TAC consists of four components, one is an antigen-binding region. This domain is responsible for the binding of tumor antigens, for example, DARPin (anti-HER2) or scFv (anti-CD19). The second part is a target scFv region that is designed for studying various antibodies from different clones. The third part is a T cell receptor recruiting region, such as the CD3 binding domain. The final part is a co-receptor region, include, CD4, CD8. TAC receptor can trigger aggregation of the native TCR following binding of tumor antigens by co-opting the native TCR via the CD3 binding domain. In these three TAC domains, each domain can be designed to use a variety of proteins, allowing the TAC to be modified to best respond to a large number of different antigens.

With our extensive experience and advanced platform, Creative Biolabs provides a comprehensive strategy for designing a variety of TAC engineered T cells for many disease therapy. This novel technology has been proven to be a safe, reliable, and effective method in several human tumor models. Besides, we are also capable of providing our clients with a variety of customized services to meet their special needs.

The innate and adaptive immune cells that are involved in TAC design.Fig.1 The innate and adaptive immune cells that are involved in TAC design. (Sharpe, 2015)

Creative Biolabs offers a series of TAC Design & Construction services which are part of our integrated portfolio of TAC engineered T cell therapy development services. With experienced teams of scientists, researchers, and technicians, we provide a fast turnaround, high-quality data at competitive prices for worldwide customers. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us for more details.


  1. Sharpe, M.; et al. Genetically modified T cells in cancer therapy: opportunities and challenges. Disease models & mechanisms. 2015, 8(4): 337-350.

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