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TAC Preclinical In Vivo Assay

Creative Biolabs provides a wide range of T Cell Antigen Connector (TAC) preclinical in vivo assays in large and small animal models for our worldwide customers. We have various platform options and will work with you to design effective in vivo studies to ensure the right tests are available and the data is accurate.

Our TAC Preclinical In Vivo Assay

Currently, scientists in Creative Biolabs have applied their training and expertise to assess the efficacy, potency, and safety of TAC technology or TAC engineered T cells in various disease modeling. We can offer comprehensive immunological assessments that range from cell characterization tests to the special construction of xenograft models. Our platform is made up of many tests for TAC preclinical in vivo studies, including but not limited to:

Construction of Animal Models

The preclinical animal models can be used to evaluate the TAC engineered T cell functions and examined their potential to predict TAC engineered T-cell driven toxicities for the future. In our platform, we have established a variety of animal models, including mice, rats, rabbits, dogs, goats, cattle, chickens, and other non-human primates to meet your requirement. Meanwhile. a strict detection system has been applied to evaluate the reproducibility and specialty of TAC engineered T cell animal models.

In Vivo Persistence and Reactivity Profile of KRAS G12D-Specific T-Cell Clones in the Infusion Product.Fig.1 In Vivo Persistence and Reactivity Profile of KRAS G12D-Specific T-Cell Clones in the Infusion Product. (Tran, 2016)

TAC Efficacy Test

TAC engineered T cell therapy has proven its success in treating hematological malignancies and solid tumors in animal models. Preclinical in vivo efficacy test of TAC-T cells in animal models are critical to the application of TAC technology in the clinic. Some of the solutions we have developed include: flow cytometry-based assays to measure immune responses to therapeutics in tissue, as well as the whole blood. Evaluation of biomarkers and checkpoints in animal models. The histological analysis for cancer or other diseases diagnosis.

Safety/Toxicity Evaluation

Recent studies show the TAC engineered T cells play an important role in anti-tumor and it should be a potential tool against diseases. Our in vivo assay is designed to assess the various aspects of the interaction between disease-related TAC-T cells and the immune system. We offer the toxicity evaluation on animal models and test the serum cytokine toxicity in TAC-T cells as well as the expression of target antigen on normal cells. The safety profile of TAC-T cells would provide evidence for making TAC therapy accessible to clinical application.

Creative Biolabs is a forward-looking company as well as a leading custom service provider in the field of TAC-engineered T cell services. We can provide many flexible in vivo assays aiming at showing efficacy and safety, from which you can always find a better match for your project. Please feel free to contact us for more information.

Reference

  1. Tran, E.; et al. T-cell transfer therapy targeting mutant KRAS in cancer. New England Journal of Medicine. 2016, 375(23): 2255-2262.

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