ANG Pep-LNP

Cat. No.: TDLD-0825-LD73

ANG Pep-LNP

ANG Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems. Engineered with the ANG peptide (Angiopep-2), this LNP system demonstrates high affinity for the low-density lipoprotein receptor-related protein (LRP) receptor. This peptide mediates the internalization of nanoparticles across the blood-brain barrier (BBB), significantly increasing their accumulation in the brain, which is 2.5 times higher than that of transferrin. Our LNP is prepared using DSPE-PEG-ANG and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of ANG Pep-LNP include targeted delivery of therapeutic agents for the treatment of neurological disorders, such as glioblastoma, Alzheimer's disease, and Parkinson's disease. Please note that this product is intended for research purposes only.