Liposome technology is transforming targeted drug delivery, providing a robust platform to enhance therapeutic efficacy while reducing systemic side effects—particularly in critical fields like oncology therapeutics and advanced vaccine platforms. At Creative Biolabs, we offer a comprehensive portfolio of liposome products and custom-engineered solutions. These resources enable researchers to address intricate delivery barriers, accelerate discovery timelines, and pioneer next-generation precision medicines.
Overview
For decades, liposome technology has served as the foundational platform for targeted drug delivery, evolving significantly from a passive carrier into a sophisticated, multifunctional nanomedicine system. Liposomes are versatile, spherical vesicles featuring one or more lipid bilayers. This unique architecture enables the encapsulation of both hydrophilic and hydrophobic therapeutic agents. Crucially, the bilayer structure provides a protective barrier against enzymatic degradation and enables extensive surface functionalization. As extensively documented in the scientific literature, liposomes facilitate dual targeting strategies: passive targeting via the enhanced permeability and retention (EPR) effect, and active targeting through ligand-mediated interactions. These inherent capabilities are proving invaluable for contemporary therapeutic development, offering researchers precise spatiotemporal control over drug release profiles.
Reduced Toxicity
Liposomes can minimize drug exposure to healthy tissues, significantly reducing side effects.
Enhanced Bioavailability
By protecting the payload, liposomes increase the therapeutic agent's effective concentration at the target site.
Sustained and Controlled Release
The lipid bilayer can be engineered to release its payload over a prolonged period, prolonging the drug's half-life and achieving sustained therapeutic effects.
Versatile Payload Encapsulation
Liposomes can encapsulate a vast array of payloads, including small molecules, nucleic acids (mRNA, siRNA, CircRNA), proteins & peptides, protein degraders, and others.
Explore Our Product Portfolio
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Creative Biolabs offers a diverse and comprehensive portfolio of liposome products for your specific research needs. Our catalog includes Empty, PEGylated, functionalized liposomes (ligand-conjugated liposomes), and drug-loaded liposomes, such as clodronate and doxorubicin liposomes. We also provide fluorescent liposomes for tracking studies, immunoliposomes for targeted delivery, and liposomes with various charges (Neutral, Cationic, and Anionic). This extensive selection provides pre-formulated products to accelerate your research in targeted drug delivery.
Empty Liposomes
These are blank liposomes without any encapsulated drug, primarily used as a vital control for research experiments and comparative studies.
PEGylated Liposomes
Offer enhanced stability and prolonged circulation time, ideal for systemic delivery and passive targeting via the EPR effect.
Functionalized Liposomes
Labeled with ligands such as peptides, aptamers, or other biomolecules to enable active, targeted delivery to specific cell types.
Fluorescent Liposomes
Track biodistribution and cellular uptake with fluorescently labeled liposomes, perfect for in vitro and in vivo studies.
Charged Liposomes
Choose between Cationic and Anionic liposomes to optimize for specific payloads and cellular interaction based on charge properties.
Immunoliposomes
Achieve cell-specific targeting by conjugating antibodies to direct your payload to the cells of interest.
Drug-loaded Liposomes
Explore pre-formulated liposomes with agents like clodronate or doxorubicin for preclinical research.
Our comprehensive range of liposome products offers extensive customization options, including adjustable lipid formulations, proportions, and particle sizes. If you have unique research needs, our team is ready to help.
Need a Custom Solution?
Request a Custom Service Consultation
While our product list provides a wide range of solutions, groundbreaking research often requires a custom approach. Our expert team is ready to partner with you to design and develop novel liposomal formulations tailored to your unique needs.
Co-delivery Liposome Development
Develop liposomes capable of encapsulating multiple drugs simultaneously to achieve synergistic therapeutic effects.
Stimuli-Responsive Liposomes Development
Develop liposomes that release their payload in response to specific triggers like pH, temperature, or light for precise, on-demand drug release.
Liposome Conjugation
Design and execute strategies for covalently attaching drugs, targeting ligands, or other biomolecules to the liposome surface.
Advanced Formulations & Secondary Development
Further develop liposomes into other forms, such as hydrogels, to create novel delivery vehicles for various applications.
Multivesicular Liposomes Development
Design complex liposome structures with multiple internal aqueous compartments for specialized encapsulation and controlled release mechanisms.
Comprehensive Liposome Analysis
Provide full characterization services covering morphology, encapsulation rate, stability, in vitro release, in vivo and in vitro efficacy studies.
Case Study
All
Empty Liposome
Drug-loaded Liposomes
Immunoliposomes
Stimuli-Responsive Liposomes
Empty Liposome
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Size: 136.7 nm
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PDI: 0.128
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Zeta Potential: -15.73 mV
Irinotecan Liposome
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Size: 139.22 nm
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PDI: 0.168
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Zeta Potential: -15.3 mV
Alendronate Liposome
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Size: 160.99 nm
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PDI: 0.205
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Zeta Potential: -32.36 mV
NTA(Ni) Liposome
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Size: 54.54 nm
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PDI: 0.220
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Zeta Potential: -43.32 mV
pH-Responsive Liposome
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Size: 127.46 nm
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PDI: 0.214
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Zeta Potential: -43.73 mV
Applications of Liposomes
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Oncology: Liposomes are widely used in oncology to deliver chemotherapeutic agents, such as Doxorubicin, directly to tumor sites, minimizing systemic toxicity and increasing therapeutic efficacy.
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Vaccine Development: As a powerful adjuvant and delivery system for antigens and nucleic acid-based vaccines, liposomes enhance and modulate the immune response.
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Payload Encapsulation: Liposomes' unique amphiphilic structure makes them exceptionally versatile for encapsulating a broad spectrum of payloads, such as small molecule drugs, nucleic acids, proteins & Peptides, antibodies, vitamins, diagnostics, contrast agents, and others.
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Cell-specific Targeting: Immunoliposomes and functionalized liposomes enable the selective delivery of payloads to specific cell types, such as cancer or immune cells, for precision therapy.
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Diagnostics & Imaging: Fluorescent liposomes, incorporating dyes, are a valuable tool for fluorescence tracking to study biodistribution, cellular uptake, and membrane fusion in diagnostic and imaging applications.
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Disease Treatment: Liposomal formulations for various diseases are engineered to achieve sustained drug release, improving therapeutic efficacy.
Why Choose Creative Biolabs?
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Deep Scientific Expertise: With over 20 years of experience, our team possesses a profound understanding of liposome chemistry, targeted delivery, and therapeutic applications to guide your project to success.
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Unmatched Customization: We offer a highly flexible platform, from custom lipid formulations and particle sizes to novel ligand conjugations, ensuring your liposomes are perfectly tailored to your research needs.
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Integrated R&D Support: Our support goes beyond products. We partner with you from initial design to comprehensive analysis, offering characterization, stability, in vitro, and in vivo validation services.
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Commitment to Quality: We maintain rigorous quality control standards, ensuring all our products and services deliver high purity, consistency, and reliability for reproducible results.
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Innovative Solutions: Our team stays at the forefront of nanomedicine, providing cutting-edge solutions like stimuli-responsive and multi-drug co-delivery liposomes to push the boundaries of research.
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Collaborative Partnership: We don't just supply products; we become a partner in your research. Our client-centric approach ensures a seamless and productive collaboration from concept to conclusion.
Product Ordering Process
FAQs
What types of payloads can be encapsulated in Creative Biolabs’ Liposomes?
Our liposomes can encapsulate a broad range of therapeutic payloads, including small molecule drugs, nucleic acids (e.g., siRNA, mRNA), proteins, and peptides. Their versatile structure allows for both hydrophilic and hydrophobic agents.
What is the benefit of using PEGylated Liposomes?
PEGylated liposomes are coated with Polyethylene Glycol (PEG), which forms a protective layer. This layer prevents opsonization and clearance by the reticuloendothelial system (RES), significantly prolonging the liposomes' circulation time and allowing for improved passive targeting.
What is the difference between passive and active targeting?
Passive targeting relies on the liposome's size and surface properties to accumulate in areas with leaky vasculature, such as tumors (the EPR effect). Active targeting involves conjugating a specific ligand (like an antibody or peptide) to the liposome surface, which binds directly to a receptor on a target cell, enabling highly selective delivery.
Can your liposomes be used for fluorescence tracking?
Yes, our fluorescent liposomes are pre-labeled with fluorescent dyes, making them an ideal tool for fluorescence tracking studies. This allows researchers to visualize the liposomes' biodistribution, cellular uptake, and membrane fusion both in vitro and in vivo.
How should I store liposome products to maintain their stability?
To ensure optimal stability and long-term integrity, liposome products should be stored according to the specific instructions on the product label. This typically involves refrigeration at 2-8°C and protection from light. Avoid freezing unless the product is specifically designed for cryopreservation.
For Research Use Only.
