CTT2 Pep-LNP

Cat. No.: TDLD-0825-LD82

CTT2 Pep-LNP

CTT2 Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems. Engineered with the TAT peptide, this LNP combines the CTT2 peptide's inherent ability to promote crossing of the cell membrane, driven by its positive charge interacting with negatively charged phospholipids, with its specific targeting capability towards tumor-associated targets like MMP-2, which is highly expressed in various malignant tumors and associated with invasion and metastasis. This dual functionality facilitates both efficient cellular internalization and active targeting to the tumor microenvironment. Our LNP is prepared using DSPE-PEG-CTT2 and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of CTT2 Pep-LNP include research in targeted cancer therapy, particularly for cancers with high MMP-2 expression, enhancing drug accumulation at the tumor site, and studying the role of MMP-2 in tumor progression. Please note that this product is intended for research purposes only.