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GPC3 Pep-LNP

Cat. No.: TDLD-0825-LD104

GPC3 Pep-LNP

GPC3 Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems. Engineered with the GPC3 peptide, this LNP specifically recognizes and binds to Glypican-3 (GPC3) protein expressed on the surface of cancer cells, enabling targeted delivery of the therapeutic payload directly to the tumor site. Our LNP is prepared using DSPE-PEG-GPC3 and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of GPC3 Pep-LNP include developing highly specific cancer therapeutics, particularly for GPC3-expressing tumors like hepatocellular carcinoma, creating targeted imaging agents, studying the role of GPC3 in tumor biology, and evaluating novel strategies for selective cancer treatment with reduced side effects on healthy cells. Please note that this product is intended for research purposes only.

SPECIFIC INQUIRY
Payload:
Modification:
Lipid Formulation:
Dye:
Concentration:
Quantity:
Inquiry
For Research Use Only. Not for Diagnostic or Treatment Applications.
Payload Type mRNA
Payload Empty; EGFP mRNA; Firefly Luciferase mRNA; mCherry mRNA; GFP mRNA; OVA mRNA; EPO mRNA; Renilla Luciferase mRNA; Gaussia Luciferase mRNA; Beta-galactosidase mRNA; Cre mRNA; mOrange mRNA; tdTomato mRNA; EYFP mRNA
Capping Cap 1
Modification Unmodified; N1-methyl-pseudouridine; 5-methoxyuridine
Module Type Peptide
Targeting Module GPC3 Peptide
Target Tumor cells
Lipid Formulation DLin-MC3-DMA; LP-01; ALC-0315; SM102
Dye Unlabeled; DiR; DiD; DiO; DiI
Application Control; Targeted Delivery; Gene Therapy
Concentration 0.1 mg/mL; 0.2 mg/mL; Other (Please Specify)
Size 65-120 nm
PDI < 0.2
Zeta ± 20.0 mV
Encapsulate Efficiency >90%
Storage Store at 2-8°C
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