MPG Pep-LNP

Cat. No.: TDLD-0825-LD101

MPG Pep-LNP

MPG Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems. Engineered with the MPG peptide, a pH-responsive cell-penetrating peptide typically composed of multiple lysine (K) and arginine (R) residues, conferring strong cationic properties. This LNP exhibits increased affinity for cellular membranes upon exposure to lower pH environments, such as those found in endosomes or the tumor microenvironment, as the amino groups on the peptide can become protonated, facilitating the penetration and release of the encapsulated cargo into the cytoplasm. Our LNP is prepared using DSPE-PEG-MPG and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of MPG Pep-LNP include improving the delivery of nucleic acids or drugs into cells, particularly in acidic microenvironments like tumors, overcoming endosomal escape barriers, studying pH-dependent cellular uptake mechanisms, and developing novel strategies for targeted cancer therapy or gene delivery. Please note that this product is intended for research purposes only.