NGR Pep-LNP
Cat. No.: TDLD-0825-LD77
NGR Pep-LNP
NGR Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems to tumor vasculature. Engineered with the NGR peptide, this LNP specifically recognizes and binds to aminopeptidase N (CD13) expressed on the surface of vascular endothelial cells within the tumor microenvironment. CD13 exhibits significantly higher expression on neovasculature and tumor cells compared to normal tissues, enabling the NGR Pep-LNP to selectively accumulate at the tumor site. Our LNP is prepared using Targeting Module and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of NGR Pep-LNP include research in anti-angiogenic therapy, tumor microenvironment modulation, and targeted cancer treatment strategies. Please note that this product is intended for research purposes only.
| Payload Type | mRNA |
| Payload | Empty; EGFP mRNA; Firefly Luciferase mRNA; mCherry mRNA; GFP mRNA; OVA mRNA; EPO mRNA; Renilla Luciferase mRNA; Gaussia Luciferase mRNA; Beta-galactosidase mRNA; Cre mRNA; mOrange mRNA; tdTomato mRNA; EYFP mRNA; Others |
| Capping | Cap 1 |
| Modification | Unmodified; N1-methyl-pseudouridine; 5-methoxyuridine; Other |
| Module Type | Peptide |
| Targeting Module | NGR Peptide |
| Target | Aminopeptidase N (CD13) |
| Lipid Formulation | DLin-MC3-DMA; LP-01; ALC-0315; SM102; Other |
| Dye | Unlabeled; DiR; DiD; DiO; DiI; Other |
| Application | Targeted Delivery; Gene Therapy |
| Format | Liquid |
| Concentration | 0.1 mg/mL; 0.2 mg/mL; Other (Please Specify) |
| Size | 65-120 nm |
| PDI | < 0.2 |
| Zeta | ± 20.0 mV |
| Encapsulate Efficiency | >90% |
| Shipping | Dry Ice |
| Storage | Store at -80°C |
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