NGR Pep-LNP

Cat. No.: TDLD-0825-LD77

NGR Pep-LNP

NGR Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems to tumor vasculature. Engineered with the NGR peptide, this LNP specifically recognizes and binds to aminopeptidase N (CD13) expressed on the surface of vascular endothelial cells within the tumor microenvironment. CD13 exhibits significantly higher expression on neovasculature and tumor cells compared to normal tissues, enabling the NGR Pep-LNP to selectively accumulate at the tumor site. Our LNP is prepared using DSPE-PEG-NGR and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of NGR Pep-LNP include research in anti-angiogenic therapy, tumor microenvironment modulation, and targeted cancer treatment strategies. Please note that this product is intended for research purposes only.