R8 Pep-LNP

Cat. No.: TDLD-0825-LD78

R8 Pep-LNP

R8 Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems. Engineered with the R8 peptide, this LNP possesses significantly improved cellular penetration capabilities. This peptide leverages its unique positive charge to interact effectively with membrane phospholipids, facilitating the traversal of the drug-loaded LNP across the cell membrane and promoting efficient internalization, thereby increasing the uptake and release efficiency of the therapeutic cargo within the target cells. Our LNP is prepared using DSPE-PEG-R8 and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of R8 Pep-LNP include research into improving the bioavailability of various therapeutic agents in hard-to-reach intracellular targets. Please note that this product is intended for research purposes only.