Organs or Tissues Targeting Services

Targeting of payloads such as drugs and imaging agents to specific organs or tissues is an attractive strategy in terms of improving the safety, the efficacy of the therapeutics and diagnostics. The use of modules in targeted therapies is advantageous due to their smaller size, reduced immunogenicity, high multivalency, deep tumor penetration, ease of synthesis, and lower production costs. As an acknowledged targeted delivery service provider, Creative Biolabs can offer various targeted delivery services and products to help our clients obtain ideal solutions contributing to your research and projects successfully.

Targeting Organs or Tissues

It is very important to develop organ or tissue-specific targeting systems to make drugs safer and more effective. Cargo molecules, like proteins, therapeutic peptides, toxins, cell-penetrating peptides (CPPs), and delivery vectors, can be linked with an active targeting module to achieve organ or tissue-specific targeting. Many successful cases prove the feasibility of this targeting approach.

• Scientists reported the first successful attempt to design and construct a novel liver-targeting fusion interferon IFN-CSP by fusing human IFN α2b with a CSP region I-plus peptide derived from Plasmodium. The purified recombinant protein IFN-CSP showed anti-HBV activity and liver targeting potentiality, providing an excellent candidate as a liver-targeting agent.


• The entry of any molecule into the brain, after parenteral administration, is largely controlled by blood-brain barrier (BBB) and there has been an increasing incidence of the use of CPPs in the transport of therapeutic molecules into the brain. However, the major challenge of using CPPs as transporters of therapeutic molecules is their non-targeting disposition. At present, this obstacle could be addressed by the use of the brain targeting moiety. These moieties could act as targeting ligands on different module delivery systems to enhance uptake of central nervous system disease (CNS) drugs into the brain.

Fig.1 The mechanism of nanomedicines of different strategies for atherosclerosis (AS) treatment.¹

• A variety of targeting moieties have been utilized with different delivery systems to target the kidney and kidney cells, including the glomerular mesangial cells, glomerular endothelial cells, and tubule cells. This strategy can give researchers a wide selection of potential targets when developing diagnostic or therapeutic strategies to renal diseases that affect particular kidney cell types.

Fig.2 The schematic of cellular uptake mechanisms of CPP or CPP/cargo.²

According to the previously reported findings, small targeting modules have been considered to be useful for a novel paradigm leading to multifunctional properties for both organ and tissue-specific disease treatment and imaging systems. Here shows organ and tissue targets that are available at Creative Biolabs.

What Can We Do for You?

Equipped with our well-established module delivery systems and experienced scientist team, we can provide either individual targeting modules or different kinds of module-payload/ carrier conjugates targeting a specific organ or tissue. A wide spectrum of corresponding products are available for your choice.

Features of Our Services:

• Various organ and tissue targets
• Different combinational strategies
• Customized products
• Fast turnaround time
• Competitive pricing
• Personalized services

By employing targeting modules to appropriate carriers, drugs have the potential to reduce side effects and toxicity associated with current therapies for organ and tissue-specific disease. Currently, targeting modules have been extensively used in medical field, no matter for treatment or diagnosis. Experienced scientists at Creative Biolabs are committed to providing high-quality targeted delivery services for various organs and tissues to contribute to the success of your project. If you are interested in the service we provide, please feel free to contact us for more detail and information.

References

1. Yang, Pingping, Jun Ren, and Lifang Yang. "Nanoparticles in the New Era of Cardiovascular Therapeutics: Challenges and Opportunities." International journal of molecular sciences 24.6 (2023): 5205.
2. Xie, Jing, et al. "Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application." Frontiers in pharmacology 11 (2020): 697.

Our services are For Research Use Only. We do not provide services to individuals.