Introduction of TAS1R1
TAS1R1 (Taste receptor type 1 member 1), a G protein-coupled receptor, is encoded by TAS1R1 gene. It mediates the perception of umami and sweet tastes and regulates metabolism. The TAS1R genes can encode heterodimeric receptors that mediate umami (hTAS1R1 + hTAS1R3) and sweet (hTAS1R2 + hTAS1R3) sensations. Studies conducted on TAS1R1 show it is the repertoire of genotypic and phenotypic marker of heightened taste sensation.
|Basic Information of TAS1R1|
|Protein Name||Taste receptor type 1 member 1|
|Aliases||GPR70, T1R1, TR1, GM148|
|Organism||Homo sapiens (Human)|
Function of TAS1R1 Membrane Protein
TAS1R1 is a component of the heterodimeric taste receptor T1R1+3, which can bind to the G protein, several studies confirm that TAS1R1 and TAS1R2 have also been shown to activate Gαo and Gαi, which can affect human sweet and amino acid taste receptors. Meanwhile, it can also inhibit adenylyl cyclases to decrease cyclic guanosine monophosphate (cGMP) levels in taste receptors. Studies show that it is related to the regulation of cyclic guanosine monophosphate (cGMP) in taste receptors. In addition, research conducted on TAS1R1 indicate that it correlates with umami and sweet taste. It also plays an important role in regulating the phosphatidylinositol (PIP2) pathway.
Fig.1 A working model for the sweet and umami taste receptor structure-function relationships. (Hong, 2004)
Application of TAS1R1 Membrane Protein in Literature
Authors analyze the available sequence variation data from the 1000 Genomes Project Phase 3 for TAS1R (TAS1R1-3) and TAS2R families studies, the data show that TAS1R1 could probably correlated with improved umami and sweet perception of TAS1R genes.
This article analyses a total of 1131 Koreans of TAS1R genes to determine whether the dietary intake is associated with Genetic variants. TAS1R1 rs34160967 may lead to the risk for GC independent of diet in Korean males.
Authors perform a meta-analysis of 20 gene expression studies and try to identify several taste-related regulatory genes. The result can extend previous genetic background of porcine umami taste.
This article aims at find whether TAS1R1 variation is associated with differences in overall taste intensity, and results indicate that SNPs (intronic rs17492553, C/T and exonic rs34160967, G/A) are associated with modest shifts in perceived intensities across all taste qualities.
This author conducts a study in chicken to investigate the effects of 5 hours fasting and 5 hours insulin immuno-neutralization on hypothalamic mRNA levels of 23 genes, including TAS1R1, and these results show it does not rely on hypothalamic abundance of the 23 transcripts analyzed.
TAS1R1 Preparation Options
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