Introduction of TAS2R14
Taste receptor type 2 member 14, also known as Taste receptor family B member 1 (TRB1), is a protein that in humans is encoded by the TAS2R14 gene. It belongs to the family of candidate taste receptors which are specifically expressed in the taste receptor cells of the tongue and palate epithelia. As a member of the G-protein-coupled receptor superfamily, TAS2R14 is organized in the genome in clusters and is genetically linked to loci that influence bitter perception in mice and humans.
|Basic Information of TAS2R14|
|Protein Name||Taste receptor type 2 member 14|
|Aliases||Taste receptor family B member 1, TRB1|
|Organism||Homo sapiens (Human)|
Function of TAS2R14 Membrane Protein
TAS2R14 is a member of the family of taste type 2 receptors (TAS2Rs) which were first identified in taste buds and subsequently discovered in extra-oral systems, where they acted with various physiological effects. During the past years, a series of studies have shown that sensing potentially harmful bitter substances in the oral cavity is achieved by the members of TAS2Rs, which are expressed in specialized sensory cells and recognize individual but overlapping sets of bitter compounds. As a member of the TAS2Rs, TAS2R14 has been proved to have extremely broad spectra for activation towards a large variety of putative bitter tastants that are structurally very divergent. This feature of TAS2R14 might explain how the limited number of bitter taste receptors enable mammals to recognize thousands of different bitter tasting molecules. What's more, it has been reported that TAS2R14 is expressed significant highly in human bronchi among the 25 TAS2Rs, indicating that TAS2R14 could be potentially used as a therapeutic target against respiratory diseases.
Fig.1 Taste receptors for five basic taste qualities and signal transduction pathways. (Kobayashi, 2010)
Application of TAS2R14 Membrane Protein in Literature
This article suggests that Saikosaponin b (SSb) is a direct TAS2R14 agonist that has the ability to inhibit IgE-induced mast cell degranulation.
This article identifies a natural agonist of TAS2R7 and TAS2R14 may play a role as a bitter receptor in satiety control and food intake.
This article indicates that the TAS2R14 gene doesn't play a major role in colorectal cancer risk in this population though there is insufficient statistical data to completely exclude the possibility that rare variants of the TAS2R14 might be involved in colorectal cancer risk.
This article suggests that TRB1 plays a role in the regulation of genes involved in the biogenesis of the translational machinery, in addition to its preferential telomeric localization.
This article shows that TRB1 could interact with p53 and suppress its tumor suppressor activity. TRB1 knockdown enhances the transcriptional activity of p53 and decreases cell viability. It indicates that TRB1 is involved in the proliferation of tumor cells by inhibiting the activities of tumor suppressor p53 in solid tumors.
TAS2R14 Preparation Options
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