Transferrin Receptor Protein Family

Transferrin receptors are carrier proteins for transferrin, which is an important chelator with a primary function of serum iron transportation, thus maintaining systemic and cellular iron homeostasis. There are two transferrin receptors that have been identified, TFR2 and TFRC. The first transferrin receptor (TFRC) is involved in iron uptake and cell growth regulation. TFRC is ubiquitously expressed in most active proliferating cell types. This receptor is capable of internalizing four ferric ions during one cycle of transferrin-mediated endocytosis. The second transferrin receptor (TFR2), as a homolog of TFRC, shares 45-66% similarity in the extracellular domain with TFRC. TFR2 is mainly expressed in tissues that are responsible for iron metabolism regulation, such as the liver and intestine. Both these receptors are transmembrane glycoproteins. Studies have found that TFR2 has a significantly decreased affinity (25-fold decrease) for transferrin compared with TFRC. However, the interactions between the transferrin peptide and these receptors are not well characterized.

TFRs are reported to be overexpressed in a number of malignant tissues. Targeting the TFRs has been shown to be effective in delivering many different therapeutic agents and causing cytotoxic effects in cancer cells in vitro and in vivo. Here, we have briefly summarized some of our current knowledge of human TRFs regarding the structure, receptor expression, roles in health and diseases and contribution to cancer therapy.

Human Transferrin Receptor Protein Members

Transmembrane proteins are challenging targets to be solubilized or stabilized in aqueous solutions without the aid of amphipathic materials. To help accelerate our understanding of different membrane proteins, Creative Biolabs has established our Magic™ membrane protein production platform, which utilizes various amphipathic materials for extraction, solubilization, and stabilization of membrane proteins, including detergents, liposomes, nanodiscs, amphipols, and SMALPs. Different approaches should be selected based on the purification, characterization, and application purposes of the proteins. We have both powerful technologies and seasoned scientists to help you find the most suitable condition for each protein.

Magic™ membrane protein production platform – Creative Biolabs

Meanwhile, to aid our clients in the discovery of highly functional anti-membrane protein antibodies, we also introduce our Magic™ membrane protein antibody discovery platform to our esteemed clients. Our services are flexible and are customized to suit your requirements. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

Online Inquiry

Verification code
Click image to refresh the verification code.


USA: 45-1 Ramsey Road, Shirley, NY 11967, USA
Europe: Heidenkampsweg 58, 20097 Hamburg, Germany
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us