Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsTransient receptor potential (TRP) channels are a group of ion channels located mostly on the plasma membrane of different cell types. In mammals, TRP channels comprise 28 members and based on the homology of amino acid sequences, they are divided into six subfamilies: TRPC (Canonical), TRPV (Vanilloid), TRPM (Melastatin), TRPP (Polycystin), TRPML (Mucolipin), and TRPA (Ankyrin). TRP ion channels are widely expressed in many different tissues and cell types. They can function as cellular sensors involved in nociception, taste perception, thermosensation, and osmolarity sensing. Besides, they also play a critical role in other physiological processes like signal transmission and ion homeostasis. Dysfunction of TRP channels can cause several inherited diseases in humans that affect the cardiovascular, renal, skeletal and nervous systems. Moreover, they are regarded as promising targets for drug discovery.
The TRPC subfamily consists of several isoforms, which are nonselective cation channels. They have a broad tissue distribution in both central nervous system and peripheral tissues. Now, these channels have gained interest as potential therapeutic targets for a variety of diseases, including respiratory diseases, neurological disorders, cardiovascular disorders, pain, cancer, etc. Small molecule inhibitors or modulators are being developed by pharmaceutical companies and academic institutes. Here, we give an introduction to the properties, functions, drug discovery of the following human TRPC channels.
For the investigations of the structure and functions of these membrane channels, Creative Biolabs uses various strategies and tools to extract and purify them, including both conventional detergent-based procedures and detergent-free methods. Aided by our cutting-edge Magic™ membrane protein production platform, we can incorporate your protein of interest in formats such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers. Different formats may be useful for different downstream applications. Aided by our expert scientists, you can always find a suitable format for your particular applications.
Meanwhile, we also run our Magic™ membrane protein antibody discovery platform to help discover anti-membrane protein antibodies using our diverse techniques. We also present DNA immunization service for anti-membrane protein antibody development. If you are interested in what we can offer, please feel free to contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
