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Transmembrane Protein Family

Transmembrane proteins (TMEM) is a kind of integral membrane proteins that exist in the total biological membrane. The TMEM family is characterized by the presence of putative transmembrane domains. A number of TMEMs have been identified and there are vastly different characteristic and localization between the members of TMEMs. As a result, the biological functions of these TMEMs differ from each other. TMEM100 is expressed in both the central nervous system and peripheral nervous system, acting as a modulator of the interaction between TRPA1 and TRPV1, which are molecular sensors and mediators of pain signals in dorsal root ganglia neurons. TMEM150C is a component of a mechanosensitive cation channel and it confers mechanically activated (MA) currents. TMEM184A acts as a heparin receptor in vascular cells and it may be involved in vesicle transport in exocrine cells and Sertoli cells. TMEM30B is an accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids.

More detailed introduction of these human TMEM members is given below. Some of these members remain to be further characterized in the future.

Human Transmembrane Protein Family Members
TMEM100 TMEM150C TMEM184A
TMEM30A TMEM30B  

The progress in the area of membrane protein functional and structural studies, as well as drug discovery research, is slowed by the requirement to develop methods and procedures suitable for expression and isolation of the target membrane proteins. With the advent of new technologies and the refinement of current strategies, increasing numbers of membrane proteins have been prepared for in vitro characterization and further applications.

To help accelerate the pace of membrane protein research, Creative Biolabs has developed our Magic™ membrane protein production platform, where we can prepare your protein of interest using detergents, liposomes, nanodiscs, lipoparticle technology, and polymers. Creative Biolabs has rich experience in screening for conditions and detergents that effectively extract the protein yet retain structure and stability.

Magic™ membrane protein production platform – Creative Biolabs

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