Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsTransmembrane proteins (TMEM) is a kind of integral membrane proteins that exist in the total biological membrane. The TMEM family is characterized by the presence of putative transmembrane domains. A number of TMEMs have been identified and there are vastly different characteristic and localization between the members of TMEMs. As a result, the biological functions of these TMEMs differ from each other. TMEM100 is expressed in both the central nervous system and peripheral nervous system, acting as a modulator of the interaction between TRPA1 and TRPV1, which are molecular sensors and mediators of pain signals in dorsal root ganglia neurons. TMEM150C is a component of a mechanosensitive cation channel and it confers mechanically activated (MA) currents. TMEM184A acts as a heparin receptor in vascular cells and it may be involved in vesicle transport in exocrine cells and Sertoli cells. TMEM30B is an accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids.
More detailed introduction of these human TMEM members is given below. Some of these members remain to be further characterized in the future.
The progress in the area of membrane protein functional and structural studies, as well as drug discovery research, is slowed by the requirement to develop methods and procedures suitable for expression and isolation of the target membrane proteins. With the advent of new technologies and the refinement of current strategies, increasing numbers of membrane proteins have been prepared for in vitro characterization and further applications.
To help accelerate the pace of membrane protein research, Creative Biolabs has developed our Magic™ membrane protein production platform, where we can prepare your protein of interest using detergents, liposomes, nanodiscs, lipoparticle technology, and polymers. Creative Biolabs has rich experience in screening for conditions and detergents that effectively extract the protein yet retain structure and stability.
Meanwhile, we introduce our Magic™ membrane protein antibody discovery platform that enables the discovery of highly functional antibodies against these membrane antigen targets. We pursue to provide you with products and services with the best quality. We also present DNA immunization service for anti-membrane protein antibody development. Please contact us to experience the great value of our services.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
