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TRPC1 Membrane Protein Introduction

Introduction of TRPC1

Transient receptor potential channel 1 (TRPC1), encoded by the gene TRPC1, is a membrane protein that can compose a non-specific ion channel permeable to calcium and many other cations. TRPC1 is considered to be induced to form channels by depletion of intracellular calcium stores and also by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system. Two transcript variants produced by alternative splicing informs have been reported for TRPC1 gene.

Basic Information of TRPC1
Protein Name Short transient receptor potential channel 1
Gene Name TRPC1
Aliases Transient receptor protein 1
Organism Homo sapiens (Human)
UniProt ID P48995
Transmembrane Times 6
Length (aa) 793
Sequence MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN

Function of TRPC1 Membrane Protein

As an ion channel, TRPC1 is located on the plasma membrane of numerous animal and human cell types, where it acts as a non-selective cation channel to transport both calcium and sodium ions. TRPC1 is able to form tetrameric complexes with TRPC4 and/or TRPC5 isoforms, which have recently been involved in the efficiency of synaptic transmission in the hippocampus. TRPC1 is considered to regulate calcium entry in response to the activation of receptors coupled to the phospholipase C system or depletion of endoplasmic calcium stores. TRPC1 has a broad expression in the brain of mammals and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. As one important member of TRPC channels, TRPC1 is shown to have diverse functions in the brain, including the control of neurite outgrowth and axon guidance, regulation of neural progenitor cells proliferation and differentiation, regulation of neuronal apoptosis or survival, modulation of neuronal excitability and excitotoxicity.

Steps in TRPC1 channel activation. Fig.1 Steps in TRPC1 channel activation. (B Pani,2012)

Application of TRPC1 Membrane Protein in Literature

  1. Wolfrum C., et al. TRPC1 regulates brown adipose tissue activity in a PPARγ-dependent manner. Am J Physiol Endocrinol Metab. 2018, 315(5):E825-E832. PubMed ID: 29989850

    This article shows that TRPC1 may be a target of PPARγ, suggesting that TRPC1 is involved in a mechanism that translates environmental or metabolic stimuli into output in the form of brown adipose tissue activity.

  2. Wang L.M., et al. Involvement of interaction between TRPC1 and Orai1 in calcium sensing receptor-mediated calcium influx and nitric oxide generation in human umbilical vein endothelial cells. Sheng Li Xue Bao. 2018, 70(3):269-280. PubMed ID: 29926068

    This article suggests that TRPC1/Orai1 may comprise a compound that regulates Ca²⁺ influx and nitric oxide production via store-operated calcium channels and receptor-operated calcium channels activation.

  3. Li M., et al. TRPC1 Null Exacerbates Memory Deficit and Apoptosis Induced by Amyloid-β. J Alzheimers Dis. 2018, 63(2):761-772. PubMed ID: 29660945

    This article confirms that the transmembrane region of TRPC1 can bind to amyloid-β protein precursor and thus decrease amyloid-β(Aβ) production, indicating that the loss of TRPC1 may exacerbate Aβ-induced cell apoptosis and memory deficit, though it does not induce cell death or impair cognitive function in physiological conditions.

  4. Jessica S., et al. Ca2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy. J Mol Cell Cardiol. 2018, 118:208-224. PubMed ID: 29634917

    This report demonstrates right ventricular specific cellular Ca²⁺ cycling remodeling in pulmonary hypertension rats with maladaptive right ventricular hypertrophy and that the STIM1L/Orai1/TRPC1/C4-dependent Ca²⁺ current participates in this Ca²⁺ remodeling in right ventricular hypertrophy secondary to pulmonary hypertension.

  5. Wang D., et al. TRPC1 Deletion Causes Striatal Neuronal Cell Apoptosis and Proteomic Alterations in Mice. Front Aging Neurosci. 2018, 10:72. PubMed ID: 29615894

    This article concludes that deletion of TRPC1 may lead to striatal neuronal apoptosis by interfering many biological processes, suggesting that TRPC1 may play a special role in the mediation of striatal cellular survival and death.

TRPC1 Preparation Options

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Reference

  1. B Pani, et al. (2016). The TR (i)P to Ca2+ signaling just got STIMy: an update on STIM1 activated TRPC channels. Frontiers in Bioscience. 17: 805-823.

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