Transient receptor potential cation channel subfamily C member 4 associated protein (TRPC4AP), also known as protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, is encoded by human gene TRPC4AP. The entire N-terminal region (AAs 1-440) of TRPC4AP is involved in its interaction with TNFRSF1A and within this region. AAs 249-440 play an important role in the interaction with TRAF2. The C-terminal region of TRPC4AP may contribute to its oligomerization. TRPC4AP has a ubiquitous expression in placenta, spleen, adrenal, appendix, bone marrow, brain, lung, and 20 other tissues. There are two putative TRAF2 binding sites, several putative Ser/Thr and Tyr kinase phosphorylation sites have been found for TRPC4AP.
|Basic Information of TRPC4AP|
|Protein Name||Short transient receptor potential channel 4-associated protein|
|Aliases||Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, TRUSS|
|Organism||Homo sapiens (Human)|
TRPC4AP, also known as TRUSS, is a substrate-specific adapter of a DDB1-CUL4-X-box (DCX) E3 ubiquitin-protein ligase complex, which is essential for cell cycle control. The DDB1-CUL4-X-box complex specifically regulates the polyubiquitination of MYC and subsequently leads to the degradation of it. TRPC4AP also plays a role in the activation of NFKB1 in response to ligation of TNFRSF1A, probably by linking TNFRSF1A to the IKK signalosome. Additionally, it is thought to be involved in the elevation of endoplasmic reticulum Ca²⁺ storage reduction in response to muscarinic acetylcholine receptor M₁ and involved in c-Jun N-terminal kinases activation via its interaction with TRAF2. The subcellular location of TRPC4AP is the plasma membrane.
Fig.1 Schematic representation of a simulated TRPC4AP structure provided by MODBASE. (Ursula, 2014)
This article suggests that the patients with this TRPC4AP haplotype may have more hallucinations and more behavioral changes when clinical phenotypes are analyzed.
This article suggests that TRPC4AP is associated with the disease in these late-onset Alzheimer's families.
This article finds that the expression of TRPC4AP is significantly down-regulated in most cancer cell lines, leading to stabilization of Myc protein.
This report suggests that TRUSS is a novel substrate of E3 ligase Skp2 and demonstrates that interruption of Skp2-TRUSS interaction by viral oncoproteins could cause pathophysiological sequelae.
This article demonstrates that the assembly of homomeric TRUSS complexes may play a role in TNF-R1 signaling.
In order to provide high-quality membrane protein preparation service, we have developed a versatile Magic™ membrane protein production platform. Our experienced scientists will do their best to help you find a perfect match in your required formats. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-TRPC4AP antibody development services.
Creative Biolabs can provide first-class membrane protein production service using a variety of strategies. Based on our leading-edge platform, we have successfully produced, purified, stabilized and characterized many challenging membrane protein targets for global customers. If you are interested in the service we can provide, please feel free to contact us for more information.