Short transient receptor potential channel 7 (TRPC7), encoded by the gene TRPC7, belongs to the subfamily C of transient receptor potential cation channels. In terms of structure, TRPC7 shares some similar characteristics with other TRPC channels, such as six transmembrane spanning segments with nitrogen (N) and carbon (C) termini residing in the cytoplasm, a pore ion path between TM5 and TM6. Only low expression of TRPC7 is detected in testis, kidney, and possibly other tissues. There are 3 isoforms produced by alternative splicing of this gene been reported.
|Basic Information of TRPC7|
|Protein Name||Short transient receptor potential channel 7|
|Aliases||Transient receptor protein 7|
|Organism||Homo sapiens (Human)|
Homologous with TRPC3 and TRPC6, TRPC7 is also activated by diacylglycerol (DAG), and TRPC7 is shown to be involved in DAG-evoked calcium signaling in HaCaT human keratinocytes. TRPC7 can form a receptor-activated non-selective calcium permeant cation channel and play important roles in biological processes, such as calcium and magnesium ion transmembrane transport, manganese ion transport, platelet activation, regulation of cytosolic calcium ion concentration, single fertilization, etc. Moreover, TRPC7 is a necessary mediator of pathologic cardiac hypertrophy, in part through a calcineurin NFAT signaling pathway. TRPC7 expression may influence sperm migration and motility. Fig.1 shows the schematic representation of the activation and regulation of TRPC channels.
Fig.1 Activation and regulation of TRPC channels. (Yuyang, 2014)
This review gives a novel view of TRPC7 mechanisms of its activation and functions in cellular physiology and pathophysiology.
This article for the first time shows that TRPC7 localizes in the surface and tubular sarcolemma of cardiomyocytes in healthy adult rats and its expression is predominantly reduced in hypertrophied cardiomyocytes from renovascular hypertensive rats, suggesting that TRPC7 may play an important role in normal physiological settings in the heart.
This article suggests that heteromeric cation channels are comprised of the TRPC3 or TRPC7 protein and the TRPP2 mutant induce enhanced influx of receptor-activated Ca(2+) that may result in dysregulated cell growth in autosomal dominant polycystic kidney disease.
This article proposes that a novel role of these members of human TRPC family may be to enhance secretion either by increasing fusion at the plasma membrane or by affecting transport through the Golgi stack.
This article suggests that the influx of Ca²⁺ through the activated TRPC7 ion channel plays a crucial role in inactivating the channel where the cooperative actions of diacylglycerol and IP3 are essentially involved.
In order to provide high-quality membrane protein preparation services, we have developed a versatile Magic™ membrane protein production platform. Our experienced scientists will do their best to help you find a perfect match in your required formats. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-TRPC7 antibody development services.
Creative Biolabs can provide first-class membrane protein production service using a variety of strategies. Based on our leading-edge platform, we have successfully produced, purified, stabilized and characterized many challenging membrane protein targets for global customers. If you are interested in the service we can provide, please feel free to contact us for more information.