Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a protein encoded by the gene TRPM7, which is mapped to the chromosome 15q21.2. Similar to other TRPs, TRPM7 comprises tetrameric ion channels with each subunit containing six-transmembrane (6 TM) segments. Notably, TRPM7 a bifunctional protein with ion channel and kinase domains in its carboxyl terminus, so it can transport ions across the cell membrane as well as transduce signals to the cytosol. TRPM7 has a broad expression in thyroid, small intestine, colon, kidney, testis, adrenal, lymph node, ovary, and multiple other tissues.
|Basic Information of TRPM7|
|Protein Name||Transient receptor potential cation channel subfamily M member 7|
|Aliases||ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK|
|Organism||Homo sapiens (Human)|
TRPM7 is an outwardly-rectifying divalent cation channel that is permeable to several divalent cations, including Zn²⁺, Mg²⁺, and Ca²⁺, as well as common monovalent cations such as Na⁺ and K⁺. TRPM7 activity is indispensable for the normal channel function, which is associated with the mediation of intracellular Ca²⁺ levels and Mg²⁺ homeostasis. So, TRPM7 is involved in multiple biological processes, such as cell adhesion, cytoskeletal organization, cell migration, embryonic development and organogenesis. It has been reported that TRPM7 is localized in the membrane of sympathetic neuronal acetylcholine (ACh)-secreting synaptic vesicles as part of a molecular complex of synaptic vesicle-specific proteins, where it participates in the regulation of anoxic neuronal cell death. Defects in TRPM7 gene have been associated with magnesium deficiency in human microvascular endothelial cells.
Fig.1 CryoEM structure of truncated mouse TRPM7. (Duan, 2018)
This article suggests that TRPM7 channel activities play a key role in high-glucose-associated endoplasmic reticulum stress and cytotoxicity via an apoptosis-inducing signaling cascade involving high-glucose, inducible nitric oxide synthase, TRPM7, other endoplasmic reticulum stress proteins, and caspases.
This article reveals that spontaneous calcium ion influx through the constitutively active TRPM7 ion channels may significantly modulate both erythroid differentiation potentials and proliferative capacity of K562 cells.
This article confirms that brain TRPM7 is essential for having normal cognitive and synaptic functions under physiological, non-pathological conditions.
This report suggests that TRPM7 plays a crucial role in a process necessary for B cell affinity maturation and the secretion of high-affinity antibodies.
This article demonstrates that a transcription factor SOX4 is uniquely sensitive to cellular tension and suggests that TRPM7 may play a special role in the progression of breast cancer via tensional regulation of SOX4.
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