TTYH1, a member of the Tweety homolog family, encodes a chloride channel restricted to neural tissue with an ill-defined role in neuron physiology. TTYH1 gene translates into a protein of 729 amino acids in human. This protein contains five transmembrane domains. Tweety homolog belongs to a family which includes three members, designated as TTYH1 (Tweety homologue 1), TTYH2 and TTYH3. Human TTYH1 gene is located at chromosome 19q13.42. It is expressed in brain, eye, ovary, and testis and at lower levels in muscle, placenta, liver and lung.
|Basic Information of TTYH1|
|Protein Name||Protein tweety homolog 1 (hTTY1)|
|Organism||Homo sapiens (Human)|
The TTYH11 protein functions as a calcium-independent, chloride channel and may be involved in cell adhesion. TTYH1 is involved in early embryonic development. The expression of TTYH1 protein is neuronal and has also been detected in neurons in vivo and in vitro. The overexpression of TTYH1 protein in cell lines and neurons in vitro leads to excessive filopodia formation. The involvement of TTYH1 has been implicated in aberrant neuronal structural plasticity in vivo, as increased TTYH1 protein expression is observed in the molecular layer of the dentate gyrus during epileptogenesis. TTYH1 is confirmed to be a potent regulator of normal TM morphology and of TM-mediated tumor-cell invasion and proliferation.
Fig.1 Schematic illustration of the role of TTYH1 for TM functions and brain tumor progression. (Jung, 2017)
This article finds that Ttyh1 might be involved in neuronal and glial cell functions. Particularly, the elevated expression of Ttyh1 in astrocytes following damaging brain insult implies some unknown role for Ttyh1 protein in brain pathology.
This article suggests that DNMT3B would represent a clear candidate for future therapies targeting these deadly tumors, which have been described by pathologists as resembling undifferentiated neural tubes.
This article suggests that ttyh1, ttyh2, and ttyh3 may play distinct roles throughout embryonic development.
This article reveals that Ttyh1 expression is increased in the dentate gyrus in an animal model of epilepsy and Ttyh1 is involved in brain pathology.
This article suggests that the Ttyh1 involves in early embryogenesis, possibly by maintaining Ca(2+) homeostasis in the endoplasmic reticulum.
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