Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsV-type proton ATPase (V-ATPase) is a proton pump that is highly conserved. It is a multi-subunit complex that consists of V0 domain responsible for the proton transport and V1 domain involved in the ATP hydrolysis. Each domain has multiple different subunits. The V0 domain includes 6 different subunits (a, d, c, c', c", and e). The V1 domain contains 8 subunits among which subunits D and F form a central rotor axle. Moreover, the V1 domain also contains tissue-specific subunit isoforms (B, C, E, and G). V-ATPase can hydrolyze ATP to drive a proton pump. It is found in the bio-membrane system, including endoplasmic reticulum, lysosomal membrane, plant tonoplasts, and the plasma membrane of prokaryotes. V-ATPase is involved in the various biological processes, such as pH homeostasis, receptor-mediated endocytosis, proteins transport, active transport of metabolites, neurotransmitter release, and tumor metastasis. Studies have shown that V-ATPase is associated with the progression of many diseases, such as osteopetrosis, distal renal tubular acidosis, X-linked myopathy with excessive autophagy.
Here shows part of V-ATPase in humans including ATP6V0A1, ATP6V0A2, ATP6V0A4, and ATP6V0C, encoded by ATP6V0A1, ATP6V0A2, ATP6V0A4, and ATP6V0C genes, respectively. They are distributed on the surface of the membrane of cell and organelle and act as the proton pumps to move protons across cell membranes involved in the multiple intracellular and extracellular processes.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
