Abuse-Deterrent Formulation (ADF) Technology

As a leader in the industry, Creative Biolabs has developed a range of formulation technologies to meet the delivery requirements of different drugs / vaccines. We have launched abuse-deterrent formulation (ADF) technology to meet these needs for drugs that are easily tampered to misuse or abuse, and some short-acting drugs that require extended action times.

Background

Drug abuse - Creative Biolabs

The usage rate of opioid analgesics is increasing year by year. The use of opioids for analgesic purposes has also greatly increased their accessibility in the population, which has made the abuse and misuse of such drugs a recognized public health hazard. Strategies to deal with this epidemic require a multidisciplinary approach, such as education, tracking, surveillance, and appropriate medication disposal. One of the important things is the development of abuse-deterrent formulations. The pharmacokinetic (PK) profile of opioids is that they are capable of achieving high concentrations in the brain in a short period of time, a result often associated with euphoria or the high, which is why drug abusers prefer them. Euphoria enhances reward behavior and leads to further abuse or misuse. Tampering is very common among prescription drug abusers, and most abusers admit that they have tampered drug delivery system in some way. In addition to chewing and swallowing, the main forms of tampering are inhalation, parenteral use, and smoking.

Abuse-Deterrent Formulation (ADF) Technology

ADFs were developed to solve the tampering with drugs that might lead to easy abuse or misuse. In general, ADFs are designed to address two major problems, one is to extend the duration time of short-acting drugs, and the other is to protect loads of high drug from tampering. In simple terms, ADFs can be divided into four categories, including physical or mechanical barriers, addition of harmful components, receptor agonists / antagonists, and prodrugs. An ADF technology developed by Creative Biolabs is a formulation technology of gel-based physical barriers. The formulation has a highly viscous or semi-solid structure and is capable of containing high concentrations of active compounds, which can be used once or twice a day, and more importantly, it can prevent inappropriate release of the drug or extraction of the active ingredient.

Features of ADF Technology

  • Good ability to prevent tampering
  • High drug loading
  • Release kinetics close to zero-order
  • Compatible with existing production processes
  • Scalable and cost-effective

ADF technology is a featured platform of Creative Biolabs. After years of painstaking research and extensive experimental validation, we have fully demonstrated the effectiveness of this technology in preventing drug abuse. More importantly, after continuous improvement, ADF also has the advantages of large drug loading, simple production, and low cost.


All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.


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All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

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