Alpha 1 Antichymotrypsin Antigen (VAng-Cr3858)
Alpha 1 Antichymotrypsin Antigen, Host/Source: Human Plasma. The purity is ≥95% by SDS-PAGE. It is shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Target
Alpha 1 Antichymotrypsin
Applications
Immunogen Grade.
Formulation
Lyophilized from 20 mM Tris-HCl, pH 7.4 with 150 mM NaCl.
Purity
≥ 95% pure by SDS-PAGE.
Introduction
A1ACT is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by A1ACT gene. Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. This protein is produced in the liver, and is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Alternative Names
A1ACT; AACT; ACT; GIG24; GIG25
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