Biotinylated Human OX40L Protein (Gln 51-Leu 183) [Fc] [Avi] (VAng-2641Lsx)

Biotinylated Human OX40L protein, human IgG1 Fc tag and Avi tag, was expressed in human 293 cells. (Uniprot ID: P23510-1)

Datasheet

Specifications

Source

HEK293 cells

Target

OX-40L

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

Tris with Glycine, Arginine and NaCl, pH 7.5.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CD40L is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells. It promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome.

Alternative Names

OX40L, TNFSF4, CD252, Glycoprotein Gp34, TXGP1