Biotinylated Human Shh Protein (Gln 24-Tyr 213) [His] (VAng-2754Lsx)

Biotinylated Human Sclerostin (SOST) protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAI01087.1)

Datasheet

Specifications

Source

HEK293 cells

Target

SOST

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

SOST (Sclerostin) is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Alternative Names

SOST, VBCH