Cancer Antigen CA 15-3 Protein (Human Fluids) (VAng-Wyb8628)
Datasheet
Specifications
Source
Human Fluids.
Target
CA 15-3
Type
Tumor Antigens
Applications
EIA and Western Blot.
Formulation
50 mM Phosphate, 150 mM Sodium Chloride, pH 7.4 ± 0.2.
Purity
> 98% pure by SDS-PAGE.
Storage
Store at -20°C.
Antigen Information
Introduction
CA 15-3 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein is anchored to the apical surface of many epithelia by a transmembrane domain. Beyond the transmembrane domain is a SEA domain that contains a cleavage site for release of the large extracellular domain. The release of mucins is performed by sheddases.
Alternative Names
CA 15-3; MUC 1; ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
