CpG ODN 1826 (VAdv-Ly0033)
| CAT | Size | Price | Quantity | |
|---|---|---|---|---|
| VAdv-Ly0033 |
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CpG ODN 1826, Class B (murine), a synthetic immunostimulatory oligonucleotide, TLR9 agonist vaccine adjuvant.
Datasheet
Specifications
Type
CpG
Specificity
TLR9 agonist
Product Form
White solid
Endotoxin
Lower than 1 EU/mg.
Storage
Store at -20°C.
Shelf Life
1 year.
Adjuvant Information
Introduction
ODN 1826 is a class B CpG oligodeoxynucleotide adjuvant with phosphorothioate modifications and specific CpG motifs. It stimulates robust B cell proliferation and antibody secretion by activating the TLR9 receptor. ODN 1826 also induces plasmacytoid dendritic cells (pDCs) to release proinflammatory cytokines like IL-6 and IL-12. Notably, its linear structure without palindromic sequences enhances the Th1 immune response. Extensively used in murine vaccine models, especially for anti-tumor and anti-infection studies, ODN 1826 significantly boosts antigen-specific antibody titers and CD8+ T cell activity, making it a key tool for TLR9-dependent immune activation.
Sequence
5'-tccatgacgttcctgacgtt-3' (20 mer)
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
