Cyclic [G(2', 5')pA(3', 5')p] (VAdv-Ly0019)

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VAdv-Ly0019

Cyclic [G(2', 5')pA(3', 5')p], mammalian (non-canonical) CDN-Cyclic [G(2', 5')pA(3', 5')p], a STING agonist vaccine adjuvant.

Datasheet

Specifications

Type

PRRs Agonist

Formula

C₂₀H₂₂N₁₀O₁₃P₂▪2Na

Molecular Weight

718.38

Specificity

Th1/Th2 response

Product Form

White solid

Percentage

≥ 95% by LC/MS

Endotoxin

Lower than 5 EU/mg.

Storage

Store at -20°C.

Shelf Life

1 year.

Adjuvant Information

Introduction

c-GpAp sodium salt, a cyclic dinucleotide, is synthesized within mammalian cells by cGAMP synthase when cytoplasmic double-stranded DNA is detected. This molecule plays a crucial role in triggering innate immune responses through direct interaction with STING (stimulator of interferon genes), a receptor located in the endoplasmic reticulum.