Design of Arenavirus Based Vaccines for Cancer
Creative Biolabs is a professional CRO that assists clients with vaccine development. We have been in this field for more than ten years, and we have served customers all over the world, and they generally give us high evaluation. Integrating the highest quality research team with the most reliable supporting facilities, coupled with a highly responsible and serious attitude, is the only magic weapon for us to have the highest reputation in the industry. Now we have established a comprehensive vaccine development system. From the development of vaccines for infectious diseases to the development of cancer vaccines, we have gone through extensive research and trials. Numerous successful cases have proved our strength.
Background
For the control of infectious diseases caused by bacteria, viruses, etc., vaccines have proven to be an extremely effective strategy, and vaccines are therefore considered to be one of the greatest medical inventions. Nowadays, vaccines are not limited to being used for the prevention of such infectious diseases. For tumors, chronic diseases, neurodegenerative diseases, and even metabolic diseases such as diabetes, vaccines are gradually playing more and more important role. There are a variety of vaccines for the prevention and treatment of cancer in the market, and a large number of preclinical and clinical trials of other disease vaccines are also underway. Because a huge body of studies have found that the body's own immune system is the most vital and effective weapon for humans to fight disease. The vast majority of diseases occur because the function of the immune system is suppressed, and the vaccine is the magic weapon for reawakening its function.
Arenavirus Based Vaccines
Traditional vaccines are generally attenuated or inactivated pathogens, primarily for infectious diseases. In recent years, viruses have received increasing attention as vaccine vectors because they are capable of inducing strong immune responses without the aid of adjuvants. Currently used viral vectors include adenoviruses, poxviruses, and alphaviruses, but these live viral vectors often involve pathogenicity, so the pursuit to find safer immunogenic vectors still requires effort.
Arenavirus is an enveloped double-segment (L segment and S segment) negative-strand RNA virus that encodes four proteins: RNA-dependent RNA polymerase L, ring-finger motif containing Z protein, nucleoprotein NP, and the glycoprotein GPC. Arenaviruses can target antigen-presenting cells such as dendritic cells and macrophages early in infection, and they have multiple strategies to evade the host's natural immune recognition. There are at least 24 currently known species belong to arenavirus family, many of which are believed with potential in prophylactic and therapeutic applications. Lymphocytic choriomeningitis virus (LCMV) is one of them which has been used over ten years in research and has been identified as a useful tool as vaccine vector as it has been proved to be able to elicit the most potent immune responses. Moreover, LCMV with genetically engineered tri-segmented genome has been showed comparable expression levels of foreign genes of interest to that of indigenous viral gene products. Another arenavirus- recombinant tri-segmented Pichinde virus (PICV), is more advantageous in avoiding pre-existing anti-vector immunity (a troublesome issue which often needs extra efforts when using viral vectors as vaccines) as it is only found in Colombia, South America.
Strengths of Using Arenavirus as Vaccine Vector
- Able to accommodate multiple foreign antigens into genome
- Capacity to stimulate robust humoral and cell-mediated immune responses
- Less or none pre-existing anti-vector immunity, avoiding being neutralized by vector-specific antibodies
- Repeated administrations possibility
- Wide tropism against many different cell types and organisms
- Self-adjuvanted and well-tolerated
As the leader in vaccine development in the industry, Creative Biolabs not only gets a good lead of its competitors in terms of professional team, but we also have the most advanced research facilities and technology. We will treat each of your commissions with the most rigorous attitude and the most exquisite abilities!
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
