Design of Experiment (DOE)-based Formulation Platform

Creative Biolabs has established a comprehensive empirical and design of experiments (DOE)-based formulation platform which can help you explore the best formulations with high success rate and short timeline. Our platform could minimize time, energy and supplies while maximizing product performance.

Design of Experiments (DOE) and Vaccine Formulation

Design of Experiments (DOE) is a technique for developing experimental matrix designs which requires specific inputs, measurable results, weighted benefits, and experience with review outputs. DOE allows for structured, statistically robust material development and generates predictive tools to determine the best formulation from the fewest experiments. Although DoE cannot replace intuition and inspiration, careful use of this technique can efficiently explore large parameter spaces.

Design of Experiment (DOE)-based Formulation Platform - Creative Biolabs

Empirical & DOE-based Excipients Selection and Formulation Development

A mixture can be defined as a combination of ingredients, where the response is a function of the ratio of the ingredients rather than the amount. Formulation development usually comes down to determining the best combination of ingredients in the mixture. Traditional experimental methods only change one component of the formulation at a time, and this method easily ignores the interaction of factors or components. The statistically based on Design of Experiments (DOE), on the other hand, provides a validated model, including any important interactions, so that the response measurements as input functions can be confidently predicted. These designs include all combinations of high and low levels of each factor. Because of the large number of factors, only a small portion of the operation needs to be done to produce estimates of the main effects and simple interactions.

Creative Biolabs offers advanced formulation development services that obtain the best formulation in the shortest amount of time by calculating the model that predicts the effect of individual excipients and the interaction between individual excipients. By using DOE to quickly identify interactions between ingredients and reduce the number of experiments required to optimize formulations, scientists have dramatically reduced the time required for formulation development. All our experiments are operated under a certified quality management system.

Features

  • Comprehensive formulation database
  • Customized algorithms with strong predictive power
  • Quickly identify of interactions between ingredients
  • Fast and accurate results
  • Saving time, energy and supplies
  • Fewer experiments and efficient lower cost
  • Predicting the effect of individual excipients and the interaction between individual excipients
  • Certified quality management system

Creative Biolabs will help you plan the shortest path to improved product performance. Our platform enables us to reduce the time required for formulation development by using DOE to quickly identify interactions between ingredients and reduce the number of experiments required to optimize the formulation. Please contact us for more details.


Our services are for research use only. We do not provide services directly to individuals.


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Tel: 1-631-466-5530
Fax: 1-631-207-8356
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Heidenkampsweg 58, 20097 Hamburg, Germany
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