Design of Listeria Monocytogenes Based Vaccines for Cancer

Creative Biolabs is a world leader in the field of cancer vaccine development. With our extensive experience and advanced platform, we are therefore confident in offering the best development services for listeria monocytogenes-based vaccines. We guarantee the finest results for our customers all over the world.

Listeria Monocytogenes - Creative Biolabs

Listeria Monocytogenes

Listeria monocytogenes (LM) is a Gram-positive bacterium, in the division Firmicutes, named after Joseph Lister. It is the species of pathogenic bacteria that causes the infection listeriosis. It is a facultative anaerobic bacterium, capable of surviving in the presence or absence of oxygen. It can grow and reproduce inside the host's cells and is one of the most virulent foodborne pathogens, with 20 to 30% of food borne listeriosis infections in high-risk individuals may be fatal. Its ability to grow at temperatures as low as 0℃ permits multiplication at typical refrigeration temperatures, greatly increasing its ability to evade control in human foodstuffs.

Listeria Monocytogenes as a Vaccine Vector

Listeria monocytogenes is a foodborne pathogen capable of colonizing a number of organs, which can result in death for an animal or, more rarely, a person. Not only does the Listeria bacterium act as a natural adjuvant capable of eliciting a powerful cell-mediated immune response, but in attenuated Listeria immunotherapeutics, the bacterium is genetically engineered to secrete the tumor associated antigen fused to a molecular adjuvant that also enhances the overall immune response. Listeria monocytogenes infects phagocytic cells such as macrophages, neutrophils, and dendritic cells and will induce a potent CTL response downstream from the initial course of infection. After phagocytosis of Listeria, the bacteria can escape from the phagolysome into the cytosol of the APC by producing the hemolytic protein, LLO, which is degraded in the cytosol by the proteosome to prevent host cell lysis. In the cytosol, Listeria expresses the actin-polymerizing protein, ActA, which allows it to spread from cell to cell. These virulence factors, LLO, ActA, and others, are under the control of a pluripotential transcription factor, PrfA. Once Listeria escapes the phagolysome, it can induce the production of IL-12, IL-6, and TNFα and enhance DC maturation. In addition to inducing the production of nitric oxide (NO) by macrophages, Listeria can also induce a rare DC subset to produce NO and TNFα. Although antibody responses to Listeria can be measured in some model systems, cellular immunity is the key to clearing infections.

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