High-density Lipoprotein-based Drug Delivery Vehicle
The success of vaccine's efficacy requires not only the appropriate antigen to stimulate strong immune responses, but also the proper delivery method to transport the vaccine to the target location. Creative Biolabs, as an outstanding vaccine development expert in the industry, also has rich experience in vaccine delivery. We have a variety of mature vaccine delivery technologies, and our experts can choose the most suitable method for you according to the specific properties of your vaccine.
Background
To date, infectious diseases eradicated by humans have all been achieved through vaccines. In addition to their role in defending against infectious diseases, the launch of cancer vaccines and the gradually proven strong efficacy also show that vaccines have incomparable advantages in preventing and treating cancers. The immune effect of the vaccine depends on many factors such as the choice of antigen and adjuvant, the route of delivery and the delivery system. Among them, the delivery system can carry the antigen substance to the body's immune system, and store the antigen for a long time in the body and assist the antigen to function. It can even change the way the antigen is presented, recruit antigen-presenting cells, protect the antigen, and affect antigen localization, etc.
High-density Lipoprotein-based Drug Delivery Vehicle
Therefore, the delivery system can not only affect the efficacy of the vaccine but also have important practical significance for the numbers of immunizations and vaccination procedures. High-density lipoproteins (HDL) are naturally occurring nanoparticles in the body, composed of a variety of biological macromolecules, and because of their unique properties, they have increasingly become an attractive means of drug delivery. Its excellent advantages for drug delivery include: 1) they are substances inherent in the organism, which can be completely degraded and have outstanding biocompatibility; 2) attributed to their endogenous, they are non-immunogenic and can avoid being cleared by the mononuclear phagocyte system (MPS); 3) be able to bind to cellular receptors such as scavenger receptor class B type 1 (SR-B1) and ATP-binding cassette transporter G1 (ABCG1), which are abundant in liver cells, macrophages and cancer cells, so they have the potential to target these cells to transport drugs; 4) previous studies have shown that lipids, proteins and microRNAs can be transported by endogenous HDL, so they have the ability to deliver multiple types of drugs.
Fig.1 Schematic of discoidal and spherical rHDL as drug delivery systems. (Ma X and Song Q, 2018)
Our Services for High-density Lipoprotein-based Drug Delivery
- Construct and preparation of HDL with controllable physicochemical properties
- Incorporation of various drugs into HDL
- Multiple strategies to endow HDL formulations with desirable targeting and penetrating abilities
- Other custom services regarding HDL-based delivery
Creative Biolabs is an industry-leading vaccine developer with a full line of vaccine development systems, including first-class adjuvant design and development capabilities. Our adjuvant development team specializes in the development of various types of adjuvants, including traditional and new adjuvants. If you have any needs in this regard, please contact us!
Reference
- Ma X, Song Q; (2018). “Reconstituted high-density lipoproteins: novel biomimetic nanocarriers for drug delivery.” Acta Pharm Sin B. 8(1): 51-63.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
