Human CD170 Protein (Glu 17-Thr 434) [Fc] (VAng-2721Lsx)
Human Siglec-5 (CD170) protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: AAH29896)
Datasheet
Specifications
Source
HEK293 cells
Target
SIGLEC5
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Tris with Glycine, Arginine and NaCl, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5) is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Alternative Names
SIGLEC5, OB-BP2, CD170, CD33L2
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