Human CD33 Protein (Asp 18-His 259) [Llama IgG2b Fc Tag] (VAng-2717Lsx)
Human Siglec-3 (CD33) protein, Llama IgG2b Fc Tag, was expressed in human 293 cells. (Uniprot ID: AAH28152.1)
Datasheet
Specifications
Source
HEK293 cells
Target
CD33
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Tris with Glycine, Arginine and NaCl, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD33 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity. It is the target of gemtuzumab ozogamicin, an Antibody-drug conjugate for the treatment of patients with acute myeloid leukemia.
Alternative Names
CD33, SIGLEC3, gp67
Related Product
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