Human ICOS Protein (Glu 21-Phe 141) [His] [Avi] (VAng-1736Lsx)

Biotinylated Human ICOS (CD278), His tag and Avi tag, is expressed in human 293 cells. (Uniprot ID: Q9Y6W8-1)

Datasheet

Specifications

Source

HEK293 Cells.

Target

ICOS

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

PBS, pH 7.4.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

ICOS is a CD28-superfamily costimulatory molecule that is expressed on activated T cells. It is thought to be important for Th2 cells in particular. The protein encoded by ICOS gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses and regulation of cell proliferation. The increase served as a pharmacodynamic biomarker of anti-CTLA-4 treatment. An agonistic stimulus for the ICOS pathway during anti-CTLA-4 therapy resulted in an increase in efficacy that is about four to five times as large as that of control treatments.

Alternative Names

ICOS, CD278, AILIM, Inducible T-cell costimulator