Human IL-12B&IL12A Heterodimer Protein (Ile 23-Ser 328 (IL-12B) and Arg 23-Ser 219 (IL-12A)) [His] [Flag] (VAng-1767Lsx)
Human IL-12B&IL-12A Heterodimer protein, His tag and Flag tag, is expressed in human 293 cells. (Uniprot ID: P29460-1 (IL12B) and P29459-1 (IL12A))
Applications
SDS-PAGE; WB; ELISA.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
IL12B is a protein that in humans is encoded by IL12B gene. IL-12B is a common subunit of interleukin 12 and Interleukin 23. This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
Alternative Names
IL12B, CLMF, CLMF2, NKSF, NKSF2, p40; IL12A, CLMF, IL-12A, NFSK, NKSF1, P35
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