Human Insulin R Protein (His 28-Lys 944) [His] (VAng-1838Lsx)

Human Insulin R (INSR) protein, His tag, expressed in human 293 cells. (Uniprot ID: P06213-2)

Datasheet

Specifications

Source

HEK293 Cells.

Target

INSR

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

PBS, pH 7.4.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

INSR is a protein that in humans is encoded by INSR gene. It is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Transcription of alternative splice variants derived from the INSR gene are translated to form one of two monomeric isomers; IR-A in which exon 11 is excluded, and IR-B in which exon 11 is included. Inclusion of exon 11 results in the addition of 12 amino acids upstream of the intrinsic furin proteolytic cleavage site.

Alternative Names

INSR, Insulin receptor, IR, CD220