Human LIFR Protein (Gln 45-Ser 833) [Fc] (VAng-1885Lsx)
Human LIFR protein, Fc tag, expressed in human 293 cells. (Uniprot ID: NP_001121143)
Datasheet
Specifications
Source
HEK293 Cells.
Target
LIFR
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Tris with Glycine, Arginine and NaCl, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
LIFR (LIF Receptor Subunit Alpha) belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland.
Alternative Names
LIFR, CD118, FLJ98106, FLJ99923, SJS2, STWS, SWS
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