Human M-CSF R Protein (Ile 20-Glu 512) [Fc] (VAng-2547Lsx)

Human M-CSF R (CD115) protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: NP_005202.2)

Datasheet

Specifications

Source

HEK293 cells

Target

CSF1R

Type

Tumor Antigens

Applications

SDS-PAGE; WB; ELISA.

Formulation

PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CSF1R (Colony Stimulating Factor 1 Receptor) is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy.

Alternative Names

CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR