Human MICA Protein (Glu 24-Gln 308) [His] (VAng-2565Lsx)
Human MICA protein, His tag, was expressed in human 293 cells. (Uniprot ID: NP_000238)
Datasheet
Specifications
Source
HEK293 cells
Target
MICA
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
MICA (MHC Class I Polypeptide-Related Sequence A) is the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma.
Alternative Names
MIC-A
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