Human MUC1 Protein (Leu 1036-Gly 1155) [His] (VAng-2575Lsx)
Human MUC1 protein, His tag, was expressed in human 293 cells. (Uniprot ID: P15941-1)
Applications
SDS-PAGE; WB; ELISA.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
MUC1 is a mucin encoded by the MUC1 gene in humans. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. The protein is anchored to the apical surface of many epithelia by a transmembrane domain. Beyond the transmembrane domain is a SEA domain that contains a cleavage site for release of the large extracellular domain. The release of mucins is performed by sheddases.
Alternative Names
Mucin-1, MUC1, CD227, EMA, H23AG, KL-6, MAM6, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, CA 15-3, Episialin
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