Human RANK Protein (Ile 30-Pro 212) [Fc] (VAng-2649Lsx)
Human RANK (TNFRSF11A) protein, Mouse IgG2a Fc Tag, was expressed in human 293 cells. (Uniprot ID: Q9Y6Q6-1)
Datasheet
Specifications
Source
HEK293 cells
Target
TNFRSF11A
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Tris with Glycine, Arginine and NaCl, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
TNFRSF11A (TNF Receptor Superfamily Member 11a) is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone.
Alternative Names
CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TNFRSF11A, TRANCER, CD265 antigen, ODFROSTS, RANKLOH18CR1, NFKB activator
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