Human Serpin A8 Protein (Asp 34-Ala 485) [His] (VAng-2692Lsx)
Human Serpin A8 protein, His tag, was expressed in human 293 cells. (Uniprot ID: NP_000020.1)
Datasheet
Specifications
Source
HEK293 cells
Target
Serpin A8
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 98% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
AGT (Angiotensinogen), pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Alternative Names
Angiotensinogen, SerpinA8, AGT, ANHU
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