Human SIRP beta Protein (Glu 30-Leu 371) [Fc] (VAng-2738Lsx)
Human SIRP beta protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: O00241-1)
Datasheet
Specifications
Source
HEK293 cells
Target
SIRPB1
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Tris with Glycine, Arginine and NaCl, pH 7.5.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
SIRPB1 (Signal Regulatory Protein Beta 1) is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Diseases associated with SIRPB1 include Composite Lymphoma.
Alternative Names
CD172b antigen, CD172b, DKFZp686A05192, FLJ26614, SIRP beta 1, SIRPB1, SIRP-BETA-1, 9930027N05Rik, SIRP-beta
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