Linads™ Lipid-based Nucleic Acid Delivery System

Creative Biolabs is the leading CRO/CDMO in the vaccine industry. We have a comprehensive research team that can provide you with the most professional and efficient advice and services in the design, preparation, evaluation, formulation design and production of vaccines. Linads™ is our superior delivery technology against the issue of low-efficiency delivery posed by nucleic acid vaccine.

New Promising Vaccine- Nucleic Acid Vaccine

Nucleic acid vaccines are an ideal type of vaccine developed in recent years. It has the advantages of low cost, ability to induce comprehensive immune response and easy mass production. The naked nucleic acid vaccine can be dissolved in common salt solution and inoculated by various routes, like subcutaneous, intramuscular, intravenous injection, etc. Despite these strengths, the true potential of nucleic acid vaccines has not yet been fully exploited because some animal experiments show that these administration methods require large doses, appear low bioavailability, and stimulate poor immune effect as well as insufficient endurance. The main reason is that after naked DNA or RNA injection, most of them will be deactivated by nuclease degradation during the process of cell matrix and cytoplasm retention until transcription. In addition, the efficiency of nucleic acid vaccine transported to antigen-presenting cells is low, resulting in decreased antigen expression levels and limited immune response. In response to this problem, many scientists have focused on developing targeted delivery methods for nucleic acid vaccines to protect nucleic acid molecules from the destruction of the biological environment and efficiently introduce them into target cells.

Non-viral delivery systems that currently protect DNA and RNA and mediate their efficient transfection include liposomes, natural polymeric carriers, synthetic polymeric carriers, bacterial inoculation systems, and the like.

Linads™ - Lipid-based Nucleic Acid Delivery System

To complement and enhance Creative Biolabs' nucleic acid vaccine platform and provide effective delivery methods for other DNA or RNA vaccines, we have launched a lipid-based nucleic acid delivery system, Linads™, which has been validated by a large number of experimental cases. The Linads™ particles containing the nucleic acid vaccine rapidly enter the cell by endocytosis by interacting with the cell membrane of the target cell and are then encapsulated in endosomes. Over time, the acidity of the endosome continues to increase. Eventually, pH-mediated disruption causes Linads™ to rapidly degrade and release the nucleic acid payload. The nucleic acid molecules released in the cytoplasm interact with the transcriptional machinery and then initiate the synthesis of functional proteins.

Schematic of Linads™.

Fig.1 Schematic of Linads™.

Advantages of Linads™

  • Compatible with various types of nucleic acid molecules, including short double-stranded siRNA, long single-stranded mRNA, and double-stranded DNA
  • Ability to be applied to multiple inoculation routes
  • Can target a variety of tissues and cells of interest
  • Support repeated administration
  • Formulation process is scalable and reproducible

A good CRO should not only have excellent research capabilities, but more importantly, it can continuously develop platforms suitable for various kinds of vaccines. Creative Biolabs' strong team of scientists owns this ability. We have developed the excellent Linads™ platform for potential nucleic acid vaccines with low delivery efficiency. A large number of cases show that the platform can efficiently deliver RNA/DNA vaccines and fully give play to the vaccine's efficacy.


All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.


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All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

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