Morphine Vaccines

Opioid vaccines are currently being used as an alternative or complementary treatment for heroin addiction because of their long-term, high selectivity and few side effects. Vaccination with heroin or morphine immunogens can elicit a robust immune response and reduce heroin self-administration and other opioid-related behavioral effects in animals. Creative Biolabs is a world leader in the field of vaccines against drugs of abuse. With our extensive experience and advanced platform, we are therefore confident in offering the best development services for morphine vaccines.

Background of Morphine Vaccine

Morphine Vaccines– Creative Biolabs

Opioids are the most widely abused illicit drugs worldwide, leading to health problems, criminal activities and financial burdens. Preventing relapse is one of the most challenging problems in addiction treatment. Currently, some agents are available for the maintenance of opioid abstinence. However, its application is limited due to its large side effects. Therefore, Therefore, there is a need for an ideal therapy with long-lasting therapeutic effects and few side effects to enhance treatment adherence and prevent recurrence.

Although vaccines against stimulant addiction have been developed recently, a vaccine directed at morphine was first tested in animals 40 years ago. Vaccines were prepared by attaching morphine hapten to bovine serum albumin (BSA) through 6-succinylmorphine (6-SM) linkage to a lysine residue on BSA. Early studies have shown that this vaccine could produce specific antibodies for heroin, 6-AM and morphine. Other studies have shown that the binding specificity depends on the hapten used. However, there are limitations and problems with standard drugs for opioid dependence. Therefore, the vaccine approach for opioid-dependent is being reinvestigated. For example, the bivalent morphine-heroin vaccine developed using tetanus toxoid as a carrier protein produces antibodies and prevents heroin self-administration in rats.

The Characteristics of Morphine Vaccine

Anti-addictive vaccines have distinctly different mechanisms of action from those currently used to treat heroin and morphine abuse. They do not rely on inhibiting the binding of drugs in the brain to specific receptors; instead, antibodies act as pharmacokinetic antagonists that alter the concentration-time course of drug in multiple organ systems, especially reducing drug concentrations in the brain. Morphine vaccines produce sustained levels of anti-morphine antibodies. Further, the functional consequences of the vaccine can be demonstrated by reducing the ability of morphine to support conditioned place preference, have analgesic effects and lower morphine brain levels. These characteristics support the potential of vaccines as a treatment agent for opioid dependence.

Mechanism of Action of Morphine Vaccine

Although opioids are too small to be recognized by the immune system, they can be immunogenic to bind them to foreign carrier proteins. Vaccination with heroin or morphine immunogens can cause a strong immune response. Immunotherapy has a different mechanism of action than drug therapy and is a promising alternative to prevent recurrence. The drug carrier protein conjugate vaccine stimulates the immune response to produce antibodies specific for the targeted drug. Antibodies limit the abuse of drugs to the periphery, preventing them from entering the central nervous system and functioning in the central nervous system.

The Workflow of Morphine Vaccines

Morphine Vaccines

Creative Biolabs is a leader in the field of vaccine development and has focused on the vaccines against drugs of abuse for years. We have experienced experts and advanced platforms that are able to provide excellent services. If you are interested in our services, please contact us for more details.

Reference

  1. Kosten T A, et al. (2013). A Morphine Conjugate Vaccine Attenuates the Behavioral Effects of Morphine in Rats. Prog Neuropsychopharmacol Biol Psychiatry, 45(4):223-229.

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