Mouse IL-4 R alpha Protein (Ile 26-Arg 233) [His] (VAng-1939Lsx)

HEK293 Cells.

IL4R

Tumor Antigens

SDS-PAGE; WB; ELISA.

PBS, pH 7.4.

> 95% pure by SDS-PAGE.

Store at -20°C to -80°C.

IL4R is a type I cytokine receptor. IL4R encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema.

IL4R, CD124, IL4RA