Pump^® - Osmotic Pump Based Release-Controlled Technology

Creative Biolabs brings together the world's top experts in vaccine development and pharmaceutical formulation development. In the tireless research of more than ten years, we have successfully launched a series of high-quality drug delivery system technology that has been verified by a large number of experiments, and therefore serves a mass of customers with extremely high quality. Pump^® is a delivery system characterized by zero-order release kinetics with osmotic pressure as the release power.

Background

The development of the dosage form has gone through four stages. The first generation is a common preparation such as tablets, capsules, injections, pills, etc. The second generation is a sustained-release preparation such as a sustained-release matrix tablet or an implantable long-acting preparation. The third generation is utilization of targeted preparations prepared from pharmaceutical carriers such as monoclonal antibodies, liposomes, microparticles, and nanoparticles, such as osmotic pump preparations, membrane controlled-release preparations, etc. And the fourth generation is a drug delivery system that targets cell-level based on in vivo feedback information.

Pump^® - Osmotic Pump Based Release-Controlled Technology

The development trend of pharmaceutical dosage forms is precise administration, targeted localization, and on-demand administration. The factors that should be considered in the design of controlled release preparations include the dose of the drug, the solubility, the pKa, the partition coefficient of oil and water of the drug, the stability of the drug in the gastrointestinal tract, and the biological factors such as biological half-life, absorption and metabolism. With osmotic pressure as the driving force, the drug release can be controlled to release the drug evenly and at a constant rate, achieving zero-order release of the drug. This is a commonly used drug release mechanism. Pump^® was developed using this mechanism. The release of drugs using this drug release mechanism is not affected by factors such as media environment pH, gastrointestinal motility, food, etc., and the correlation between in vitro experiments and in vivo performance is better.

Pump^® delivers vaccines, drugs, hormones, and other agents at a controlled rate for up to six weeks. And this technology does not need to be connected to external devices and does not require frequent operations. In addition to being used for systemic administration, Pump^® can also be attached to a catheter for infusion of drugs into the brain, veins, and arteries, and can even target specific tissues or organs to deliver drugs.

After more than ten years of development, Creative Biolabs has not only established a complete vaccine and dosage form development system, but also established a comprehensive and high-quality service system. If you have any need for vaccine development or formulation development, we will be your most reliable partner!

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.