Recombinant 4-1BB Ligand / TNFSF9 Protein (Arg 104-Glu 309) [Fc] (VAng-0695Lsx)
Mouse 4-1BB ligand, human IgG1 Fc tag, was expressed in HEK 293 cells, with a molecular weight of 60-70 kDa. (Uniprot ID: NP_033430)
Applications
SDS-PAGE; WB; ELISA.
Formulation
50 mM Tris, 100 mM Glycine, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
4-1BBL is found on APCs (antigen presenting cells) and binds to 4-1BB. Therapies utilizing the 4-1BB:4-1BBL signaling pathway have been shown to have antitumor effects in a number of model systems. It is a membrane bound member of the TNF superfamily that is expressed on activated B-cells; macrophage; and dendritic cells. The ligand is specific for the 4-1BB receptor and may play a role in inducing the proliferation of activated peripheral blood T-cells.
Alternative Names
4-1BB ligand; TNFSF9; CD137L
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